Endocrine Abstracts

Introduction: Albright’s Hereditary Osteodystrophy (AHO, Pseudohypoparathyroidism type 1a) is inherited in an autosomal dominant manner. End-organ resistance is seen, primarily affecting parathyroid hormone (PTH) and thyroid hormones (TSH). The manifestation of hormone resistance, in particular resistance to PTH, depends on whether the mutated allele is inherited maternally or paternally.Cases: A 4 year old male child was incidentally found to have ...

Baseline cortisol values may not necessarily rule out Addison’s disease. We report a case with vague symptomatology,normal coritsol baseline values with high index of suspicion and positive low dose synacthen test which lead up to the diagnosis. Young boy age 9 presented with low serum sodium levels and intermittent concern with abdominal symptoms, exhaustion and altered behaviour. He had normal baseline pituitary function including cortisol of 223 that decreased to 156 (...

Aim: Previous studies have shown that diabetes associated antibodies are present in 85–90% of patients with Type 1 diabetes. NICE guidelines do not suggest routine use of antibodies screening at initial presentation. The aim of our study was to identify the incidence of antibody positivity in our centre and also review the clinical profile of children diagnosed with diabetes who were antibodies negative.Method: Retrospective case notes review of 243...

Background: Long term remission in paediatric onset hyperthyroidism (HT) is low at 20–30% compared to 40–50% in adult onset HT. There are very few studies which report long-term follow-up of paediatric onset HT especially into adulthood and factors which can predict a need for definitive treatment in the long-term.Objectives: To evaluate the long-term outcome of paediatric onset HT with follow-up into adulthood and identify any early predictors...